Automated Fluorescence Microscope for Next Generation Sequencing

Finding themselves with a suboptimal optics solution after acquiring its original developer, Volpi came to us to optimize the design and industrialize the assembly and testing of the module.

Discipline:
Next Gen. Sequencing Next Gen. Sequencing

Customer Requirements

  • An optoelectronic expert for systems engineering, industrialization, manufacturing and life cycle management
  • An established change management system
  • Expertise in tester development and build
  • Flexibility and ability to cope with strongly fluctuating demand
  • Module manufacturing in the USA

Volpi’s Solution

  • Design optimizations avoided stray light and produced excellent image quality for entire sequencing runs

Stable operation over entire sequencing runs (24 hours)

  • Design optimizations for improved mechanical and optoelectronic stability
  • Automatic tester development & builds
  • 100% QA

Reliable supply

  • Professional components supply chain management
  • Manufacturing in the USA in relative proximity to the instrument integrator
  • Coping with strongly fluctuating demand

Economic module cost through material and process cost reduction initiative at Volpi

Technical Features

  • Measurement principle:
    Fluorescence Imaging
  • Illumination:
    LED, number of optical channels: four , ultra-large field of view, high power LED excitation for high throughput imaging
  • Detection:
    CCD camera, imaging resolution better than 0.3 micrometer
  • Mechanical:
    x/y stage with optical closed-loop distance control with 0.1 µm precision
  • Automatic:
    Turn table for flow cells exchange
  • Consumable type:
    Sequencing flow cell
  • Number of different component types/module:
    158
  • Number of components/module:
    490

Technical Features

  • Measurement principle:
    Fluorescence Imaging
  • Illumination:
    LED, number of optical channels: four , ultra-large field of view, high power LED excitation for high throughput imaging
  • Detection:
    CCD camera, imaging resolution better than 0.3 micrometer
  • Mechanical:
    x/y stage with optical closed-loop distance control with 0.1 µm precision
  • Automatic:
    Turn table for flow cells exchange
  • Consumable type:
    Sequencing flow cell
  • Number of different component types/module:
    158
  • Number of components/module:
    490
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